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Its Presence in CSF and Brain Extracts of Patients With Multiple Sclerosis

Pankaj D. Mehta, PhD; Halldor Thormar, PhD; Henryk M. Wisniewski, MD, PhD

Arch Neurol. 1980;37(10):607-609.

Abstract
• Twenty of 41 patients with multiple sclerosis (MS) and five of 30 patients with other neurological diseases had measles antibody titers in their CSF when examined in hemagglutination inhibition and neutralization tests. Quantitation of measles-specific IgG in CSF of patients with MS with significant measles antibody titers showed that less than 5% of the total IgG was measles virus specific. In contrast, using the identical quantitation procedures, 30% to 60% of the total IgG in CSF of patients with subacute sclerosing panencephalitis was found to be measles specific. Thus, only a very minor portion of the total IgG in CSF of patients with MS is synthesized against measles virus. When measles hemagglutination inhibition, complement fixation, and neutralizing antibody titers were measured in individual oligoclonal IgG bands isolated from neutral pH brain extracts of two patients with MS, low titers were present in all the oligoclonal bands rather than being restricted to any single band.

Author Affiliations
From the Department of Virology, New York State Institute for Basic Research in Mental Retardation, Staten Island, NY.

Footnotes
Accepted for publication Nov 30, 1979.

Read in part before the 62nd annual Federation Meetings, Atlanta, June 6, 1978.

Reprint requests to New York State Institute for Basic Research in Mental Retardation, 1050 Forest Hill Rd, Staten Island, NY 10314 (Dr Mehta).

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