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Relation to Clinically Determined Activity, Duration, and Severity of Disease

Bernard M. Patten, MD; George Zito, MD; Yadollah Harati, MD

Arch Neurol. 1979;36(9):560-564.

Abstract
• Correlation of 18 histologic variables with age and sex of 24 patients with motor neuron disease (MND), and the duration, severity, and activity of their disease, showed that high density of atrophic fibers correlated with degree of muscle weakness and the worst prognosis and that type I grouping correlated with the best prognosis. Although both type I and type II fibers are involved in the majority of patients with MND, the data suggest that involvement of type I fibers is more important in relation to activity of the disease.

Author Affiliations
From the Division of Neuromuscular Diseases, Department of Neurology, Baylor College of Medicine, Texas Medical Center, Houston.

Footnotes
Accepted for publication Oct 31, 1978.

Reprint requests to Neuromuscular Disease Division, Department of Neurology, Baylor College of Medicine, Texas Medical Center, Houston, TX 77030 (Dr Patten).

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ABSTRACT