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Uptake and Release of Putative NeurotransmittersMeasurements in Regions of the Normal and Newcastle Disease Virus-Infected Mouse Brain
Stephen C. Bondy, PhD;
Jack S. Burks, MD;
Marilyn E. Harrington, MS
Arch Neurol. 1979;36(9):540-543.
Abstract
• The capacity of various regions of the mouse brain to accumulate a series of putative neurotransmitter compounds has been studied in cerebral homogenates. This uptake is selective, sodium dependent, energy dependent, and exhibits characteristics of high affinity transport. Calcium-stimulated release under depolarizing conditions of accumulated radioactive compounds was also examined. Large regional variations of uptake and release capacity existed. No clear relation between intensity of uptake and releasability of transported compounds was seen. The effect of infection of mice with Newcastle disease virus on these processes was investigated. No significant differences were seen in infected mice despite their depressed metabolic rate.
Author Affiliations
From the Departments of Neurology (Drs Bondy and Burks and Ms Harrington), Microbiology and Immunology (Dr Burks), and Pharmacology (Dr Bondy), University of Colorado Medical Center, and the Veterans Administration Medical Center (Dr Burks), Denver. Dr Bondy is now with the Neurochemistry Section, Laboratory of Behavioural and Neurological Toxicology, National Institute of Environmental Health Sciences, Research Triangle Par, NC.
Footnotes
Accepted for publication Oct 15, 1978.
Reprint requests to Neurology Service, VA Medical Center, 1055 Clermont St, Denver, CO 80220 (Dr Burks).
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