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Viral Antibodies in Serum and CSF of Parkinsonian Patients and Controls
Teresita S. Elizan, MD;
David L. Madden, DVM, PhD;
Gary R. Noble, MD;
Kenneth L. Herrmann, MD;
Jared Gardner, MD;
Jerome Schwartz, PhD;
Harry Smith, Jr, PhD;
John L. Sever, MD, PhD;
Melvin D. Yahr, MD
Arch Neurol. 1979;36(9):529-534.
Abstract
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• Viral antibody titers to 12 strains of influenza A virus and to 11 other viruses were determined by complement-fixation (CF), hemagglutination-inhibition (HI), and/or indirect hemagglutination (IHA) tests in the serum and cerebrospinal fluid of patients with classical postencephalitic Parkinson's disease (PEPD), idiopathic Parkinson's disease (PD), and nonparkinsonian neurological and medical diseases (controls). We found significant differences of mean serum antibody titers to several viruses in the group with PEPD and the controls. Herpes simplex virus type 1 (CF, IHA), cytomegalovirus (CF, IHA), and herpes simplex virus type 2 (IHA) mean titers were significantly lower in sera of patients with PEPD than in the sera of control patients. Herpes simplex virus 1 (IHA), measles (HI), and rubella (HI) mean titers were significantly lower in sera of patients with PD than in those of controls. Serum influenza mean titers (Hsw1N1) were significantly higher in the patients with PEPD than in the controls; but, this latter finding could not be confirmed when two additional control groups were concurrently tested. We question the biological importance of these viral agents in the etiology of Parkinson's disease and suggest that none of these viruses are causally associated with the disease.
Author Affiliations
From the Departments of Neurology (Drs Elizan, Schwartz, and Yahr) and Biostatistics (Dr Smith, Jr), The Mount Sinai School of Medicine of the City University of New York; the Center for Disease Control, Public Health Service, Atlanta (Drs Noble, Herrmann, and Gardner); and the Infectious Diseases Branch, National Institute of Neurological and Communicative Disorders and Stroke, National Institutes of Health, Bethesda, Md (Drs Madden and Sever).
Footnotes
Accepted for publication March 3, 1979.
Reprint requests to Department of Neurology, The Mount Sinai School of Medicine, Fifth Ave and 100th St, New York, NY 10029 (Dr Elizan).
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