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Effect of Physostigmine on Constructional and Memory Tasks in Alzheimer's Disease
Osamu Muramoto, MD;
Morihiro Sugishita, PhD;
Hideo Sugita, MD;
Yasuo Toyokura, MD
Arch Neurol. 1979;36(8):501-503.
Abstract
• We performed a double-blind study of the effect of physostigmine vs saline on the performance of memory and constructional tasks in a patient with probable Alzheimer's disease. On the days of physostigmine administration, a remarkable improvement in copying figures was observed. However, physostigmine administration had only a limited effect on memory performance. The results are interpreted in the context of recent biochemical studies of the brain in Alzheimer's disease, which suggest selective loss in the central cholinergic system.
Author Affiliations
From the Department of Neurology, Institute of Brain Research, Faculty of Medicine, University of Tokyo, Japan. Dr Muramoto is now with the National Center for Nervous, Mental, and Muscular Disorders, Tokyo.
Footnotes
Accepted for publication May 9, 1978.
Reprint requests to National Center for Nervous, Mental and Muscular Disorders, 2620 Ogawahigashi, Kodaira, Tokyo 187, Japan (Dr Muramoto).
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