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Its Role in Regulation of Cat Brain Extracellular Fluid

Bizhan Aarabi, MD; Mel H. Epstein, MD; Donlin M. Long, MD, PhD

Arch Neurol. 1979;36(8):498-500.

Abstract
• The role of dibutyryl cyclic adenosine 3',5'-monophosphate (db cAMP) in influencing the water content of the cat's gray and white matter was evaluated by intracortical injection of 20 µL of 2 x 10^-1 to 2 x 10^-6M solution of db cAMP. Cholera toxin, a stimulator of adenylate cyclase, also was tested. Concentrations of db cAMP less than 10^-3M failed to produce significant change in brain water content, while concentrations greater than 10^-2M produced 31.5% ± 8% and 17.3% ± 3.6% increases in white matter volume, respectively (P <.05). Cholera toxin did not increase brain water levels. These results are discussed in relation to the pathophysiology of brain edema.

Author Affiliations
From the Department of Neurosurgery, The Johns Hopkins University School of Medicine and Hospital, Baltimore, Md.

Footnotes
Accepted for publication Oct 2, 1978.

Reprint requests to 1535 McElderry St, Baltimore, MD 21205 (Dr Tousi).

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