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Dennis J. Chapron, MS; Paul A. Kramer, PhD; Sandra L. Mariano; David C. Hohnadel, PhD

Arch Neurol. 1979;36(7):436-438.

Abstract
• The effects of bihourly administration of gluconate calcium and two magnesium-aluminum—containing acids on the bioavailability of a single capsule dose of phenytoin sodium were determined in two normal volunteers. Neither the rate nor the extent of phenytoin absorption were altered by the treatments, in spite of indirect evidence from other studies that might suggest such an interaction. No interaction between calcium or magnesium and either unionized or anionic phenytoin could be demonstrated in vitro using solubility and spectral techniques.

Author Affiliations
From the School of Pharmacy, University of Connecticut, Storrs (Mr Chapron, Dr Kramer, and Ms Mariano); and the Departments of Pharmacy (Mr Chapron and Dr Kramer) and Laboratory Medicine (Drs Hohnadel and Kramer), University of Connecticut Health Center, Farmington.

Footnotes
Accepted for publication March 9, 1978.

Reprint requests to Department of Pharmacy, University of Connecticut Health Center, Farmington, CT 06032 (Mr Chapron).

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