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Studies in Normal Subjects and Subjects With Risk Factors for Atherothrombotic Stroke

Hiroaki Naritomi, MD; John Stirling Meyer, MD; Fumihiko Sakai, MD; Fumie Yamaguchi, MD; Terry Shaw, PhD

Arch Neurol. 1979;36(7):410-416.

Abstract
• Regional cerebral blood flow (rCBF) was measured by¹³³Xe inhalation in 46 normal volunteers, aged 21 to 63 years, and 14 neurologically asymptomatic subjects above age 40 with risk factors for atherothrombotic stroke, including hypertension, diabetes mellitus, and hyperlipidemia. In normal volunteers, there was diffuse and progressive reduction of gray matter flow and weight as well as increases of cerebrovascular resistance (CVR) with advancing age. Reduction of gray matter flow with advancing age appears to be attributed in part to neuronal atrophy and in part to cerebral arteriosclerosis. Regional increases of CVR and reduction of gray matter flow with advancing age were most evident in the middle cerebral arterial (MCA) distribution and were enhanced by the association of risk factors. Development of cerebral arteriosclerosis with age and/or risk factors appears to be most evident in MCA distribution.

Author Affiliations
From the Department of Neurology, Baylor College of Medicine, Baylor Center for Cerebrovascular Research, and the Cerebral Blood Flow Laboratory, Veterans Administration Hospital, Houston.

Footnotes
Accepted for publication Sept 7, 1978.

Reprint requests to Cerebrovascular Research, Veterans Administration Hospital, 2002 Holcombe Blvd, Houston, TX 77211 (Dr Meyer).

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