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Sedative Effects of Apomorphine in an Animal Model of Huntington's Disease
Paul R. Sanberg, MSc;
John Lehmann;
Hans C. Fibiger, PhD
Arch Neurol. 1979;36(6):349-350.
Abstract
• The sedative effectiveness of apomorphine in a newly developed animal model of Huntington's disease was examined. The motor responses of rats with kainic acid lesions of the neostriatum to a sedative dose of apomorphine (50 µg/kg) was similar to that observed in intact controls. In contrast, compared to controls, a marked potentiation of the motor stimulant effects of dextroamphetamine was confirmed in the kainic acid-lesioned group. We suggest that the pathological changes underlying the symptoms observed in this animal model and in Huntington's disease do not include abnormalities in presynaptic dopamine receptors in the neostriatum.
Author Affiliations
From the Division of Neurological Sciences, Department of Psychiatry, University of British Columbia, Vancouver.
Footnotes
Accepted for publication May 27, 1978.
Reprint requests to Division of Neurological Sciences, Department of Psychiatry, University of British Columbia, Vancouver, British Columbia, Canada V6T 1W5 (Dr Fibiger).
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