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Evaluation in Amyotrophic Lateral Sclerosis and Late-Onset Postpoliomyelitis Progressive Muscular Atrophy

Jerome E. Kurent, MD; Benjamin Rix Brooks, MD; David L. Madden, DVM, PhD; John L. Sever, MD, PhD; W. King Engel, MD

Arch Neurol. 1979;36(5):269-273.

Abstract
• Serum and CSF from 48 patients with amyotrophic lateral sclerosis and six patients with late-onset postpoliomyelitis progressive muscular atrophy were investigated for the presence of antibody to poliovirus types 1, 2, and 3, coxsackie viruses B3 and B4, influenza A, measles, rubella, mumps, herpes simplex types 1 and 2, cytomegalovirus, varicella-zoster, and Toxoplasma gondii. These results were compared with those from 53 control patients with neuromuscular disease matched for age, sex, race, and poliovirus vaccine exposure. There was no difference either in the distribution of serum or CSF antibody titers or the geometricmean antibody titers. There was no evidence suggesting the presence of locally produced specific viral antibody within the CNS to any of the agents studied. In particular, there was no serological evidence to suggest an association between persistent infection with any poliovirus type and amyotrophic lateral sclerosis or late-onset postpoliomyelitis progressive muscular atrophy.

Author Affiliations
From the Infectious Diseases Branch (Drs Kurent, Madden, and Sever), and the Medical Neurology Branch (Drs Brooks and Engel), National Institute of Neurological and Communicative Disorders and Stroke, and the Department of Neurology (Drs Kurent and Brooks), Johns Hopkins University School of Medicine, Bethesda, Md.

Footnotes
Accepted for publication Aug 28, 1978.

Presented in part at the American Academy of Neurology, Los Angeles, April 27, 1978.

Reprint requests to Medical Neurology Branch, National Institute of Neurological and Communicative Disorders and Stroke, Bldg 10, Rm 10D18, Bethesda, MD 20014 (Dr Engel).

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