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A Human Model for Studying Dopaminergic Supersensitivity

Marco Trabucchi, MD; Maria G. Albizzati, MD; Lodovico Frattola, MD; Guglielmo Scarlato, MD

Arch Neurol. 1979;36(4):246-248.

Abstract
• The observation of a patient suffering from a parkinsonian syndrome, almost entirely expressed on the right side, and "on-off" attacks with rotatory movement of the trunk, led us to consider that the rotational model of animals may be reproduced in man. The symptoms presented by our patient may reflect a predominant degeneration in the nigrostriatal pathway of the left side. We suggest that his torsion behavior is due to hypersensitivity phenomenon of the dopaminergic receptors on this side.

Author Affiliations
From the Departments of Pharmacology (Dr Trabucchi) and Neurology (Drs Albizzati, Frattola, and Scarlato), University of Milan.

Footnotes
Accepted for publication April 14, 1978.

Reprint requests to Department of Pharmacology, University of Milan, Via Vanvitelli 32, Milan, Italy (Dr Trabucchi).

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