Hemiparkinsonism. A human model for studying dopaminergic supersensitivity
M. Trabucchi, M. G. Albizzati, L. Frattola and G. Scarlato
The observation of a patient suffering from a parkinsonian syndrome, almost
entirely expressed on the right side, and "on-off" attacks with rotatory
movement of the trunk, led us to consider that the rotational model of
animals may be reproduced in man. The symptoms presented by our patient may
reflect a predominant degeneration in the nigrostriatal pathway of the left
side. We suggest that his torsion behavior is due to hypersensitivity
phenomenon of the dopaminergic receptors on this side.