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Giovanni Tredici, MD; Giancarlo Minoli, MD

Arch Neurol. 1979;36(4):236-239.

Abstract
• A sural nerve biopsy specimen was obtained from a 16-year-old girl affected by a clinically uncomplicated form of familial spastic paraplegia. The electron microscopic study evidenced degenerative changes in some large myelinated fibers. Onion bulb formations and clusters of small myelinated fibers were also observed. Quantitative determinations showed a decreased density of the large myelinated fibers and a mild decrease in the percentage of the endoneural area covered by the myelinated fibers. The unmyelinated fibers were uninvolved except for their participation in onion bulb formations.

Author Affiliations
From the Istituto di Anatomia Umana Normale, University of Milan, and Divisione Neurologica, Ospeodale Generale, Monza.

Footnotes
Accepted for publication April 3, 1978.

Reprint requests to Istituto di Anatomia Umana Normale, University of Milan, Via Mangiagalli 31, 20133 Milan, Italy (Dr Tredici).

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ABSTRACT