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Thoru Yamada, MD; Nelson Stevland, MD; Jun Kimura, MD

Arch Neurol. 1979;36(4):225-227.

Abstract
• An EEG of a two-year-old child with Reye's syndrome complicated by prolonged hypoglycemia showed continuous, diffusely distributed, 8- to 9-Hz, well-modulated alpha activity while the patient was comatose. Continuous monitoring of EEG showed gradual reduction of alpha activity and the appearance of moderate-amplitude delta waves within the next 18 hours. Subsequent EEGs showed electrocerebral silence. The EEG features and their evolution resembled those described in postanoxic "alphapattern coma" in adults. A diffuse cortical-subcortical insult, possibly due to hypoglycemia, may be responsible for the generation of diffuse alpha activity in our case. Because of its transient nature, immediate and serial EEG studies following the acute cerebral insult may be necessary to demonstrate this pattern in children.

Author Affiliations
From the Division of Clinical Electrophysiology, Department of Neurology, University of Iowa Hospitals, Iowa City.

Footnotes
Accepted for publication May 10, 1978.

Read in part before the Central Association of Electroencephalographers, Omaha, May 1978.

Reprint requests to Electroencephalographic Laboratories, University of Iowa Hospitals, Iowa City, IA 52242 (Dr Yamada).

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