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Amyotrophic Lateral Sclerosis and Parkinsonism-Dementia on Guam

Yasuho Nagano, MD; Tadao Tsubaki, MD; Thomas N. Chase, MD

Arch Neurol. 1979;36(4):217-220.

Abstract
• Studies of the endocrinologic control of carbohydrate metabolism were conducted in Guamanians with parkinsonism-dementia (PD) or amyotrophic lateral sclerosis (ALS) and in Guamanian control patients who had various other neuromuscular disorders. Intravenously infused arginine tended to produce a more prolonged elevation in serum glucose levels in PD and ALS patients than in control subjects. On the other hand, the serum insulin response to arginine was significantly less in both PD and ALS patients than in controls. Arginine stimulated the release of growth hormone to a similar degree in all three patient groups. These observations support and extend previous reports of endocrinologic abnormalities in parkinsonism and ALS and might suggest that a defect in pancreatic islet cell function attends these disorders.

Author Affiliations
From the Department of Neurology, Brain Research Institute, Niigata (Japan) University (Drs Nagano and Tsubaki), and the Experimental Therapeutics Branch, National Institute of Neurological and Communicative Disorders and Stroke, Bethesda, Md (Dr Chase). Dr Nagano is now with the Division of Neurology, Duke University Medical Center, Durham, NC.

Footnotes
Accepted for publication May 9, 1978.

Reprint requests to Division of Neurology, Duke University Medical Center, Durham, NC 27710 (Dr Nagano).

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