 |
|
CNS Changes in HyperbilirubinemiaFunctional Implications
Jean Y. Jew, MD;
Dean Sandquist, MD
Arch Neurol. 1979;36(3):149-154.
Abstract
• Hyperbilirubinemia is a recognized etiologic factor in motor and hearing disorders associated with cerebral palsy. Its role in more subtle forms of neurological impairment is more controversial. Using a mutant animal model, which develops symptoms and signs closely resembling the human kernicterus syndrome, neurons of hippocampus, cerebral cortex, cochlear nuclei, locus ceruleus, and olfactory bulb were examined by electron microscopy.
Pathological changes, observed in all areas studied, consisted of mitochondrial and endoplasmic enlargement and vacuolation, with glycogen deposition; increased extracellular space; myelin figures; and degenerating changes in nerve terminals.
If we make the assumption that pathologic changes in the human infant with neonatal jaundice are similar to changes in the animal model, then the widespread involvement of CNS neurons in all cortical areas examined may well help to explain the syndromes of minimal cerebral dysfunction reported in clinical studies.
Author Affiliations
From the Department of Anatomy, College of Medicine, University of Iowa, Iowa City.
Footnotes
Accepted for publication March 4, 1978.
Reprint requests to Department of Anatomy, College of Medicine, University of Iowa, Iowa City, IA 52242 (Dr Jew).
 CiteULike  Connotea  Delicious  Digg  Facebook  Reddit  Technorati  Twitter
What's this?
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
Acute hyperbilirubinaemia induces presynaptic neurodegeneration at a central glutamatergic synapse
Haustein et al.
J. Physiol. 2010;588:4683-4693.
ABSTRACT
| FULL TEXT
Interaction of Hemolysis and Hyperbilirubinemia on Neurodevelopmental Outcomes in the Collaborative Perinatal Project
Kuzniewicz and Newman
Pediatrics 2009;123:1045-1050.
ABSTRACT
| FULL TEXT
Bilirubin protects astrocytes from its own toxicity by inducing up-regulation and translocation of multidrug resistance-associated protein 1 (Mrp1)
Gennuso et al.
Proc. Natl. Acad. Sci. USA 2004;101:2470-2475.
ABSTRACT
| FULL TEXT
Effects of Hyperbilirubinemia on the Hearing and Vocal Development in Gunn Rats
Lenhardt
Arch Otolaryngol Head Neck Surg 1982;108:339-342.
ABSTRACT
|
