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Familial Psychosis and Diverse Neurologic Abnormalities in Adult-Onset Gaucher's Disease
John F. Neil, MD;
Robert H. Glew, PhD;
Stephen P. Peters, MD, PhD
Arch Neurol. 1979;36(2):95-99.
Abstract
• A family is described in which adult-onset Gaucher's disease developed, followed years later by atypical psychotic disorders with neurologic and electroencephalographic abnormalities. A biochemical investigation of primary and secondary enzyme alterations in the index case was performed in an attempt to identify a pattern that might be specific to this clinical profile. The literature pertaining to CNS involvement in adult patients with Gaucher's disease is also reviewed. An etiologic link may exist between the inherited metabolic disorder and associated neuropsychiatric impairment. The biochemical basis of this hypothesized association remains unclear, however, and further enzymatic and pathologic investigations are warranted.
Author Affiliations
From the Departments of Psychiatry (Dr Neil) and Biochemistry (Drs Glew and Peters), University of Pittsburgh School of Medicine.
Footnotes
Accepted for publication March 25, 1978.
Reprint requests to Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, 3811 O'Hara St, Pittsburgh, PA 15261 (Dr Neil).
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