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  Vol. 36 No. 2, February 1979 TABLE OF CONTENTS
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Brain Stem Auditory Evoked Responses

Studies of Waveform Variations in 50 Normal Human Subjects

Keith H. Chiappa, MD; Karen J. Gladstone; Robert R. Young, MD

Arch Neurol. 1979;36(2):81-87.


Abstract

• Brain stem auditory evoked responses (BAERs) were recorded in 50 normal adult subjects at various click rates. Attention was paid to absolute latencies, interwave latencies, interear interwave latencies, absolute amplitudes, and various amplitude ratios. The variability of waves VI and VII suggests that the clinical utility of these waves is restricted—their absence is not necessarily due to a CNS lesion. The wave IV-V complex appears with six different patterns and wave III with two different patterns. These variations must therefore be considered normal; none should be misconstrued as indicative of disease of the CNS. Repeated studies over a period of two to nine months showed no statistically significant changes in amplitude or latency measurements with the passage of time. Knowledge of these normal values and their variations, as a precondition for establishing criteria for abnormality, is essential to the interpretation of BAERs in clinical situations.



Author Affiliations

From the Robert S. Schwab Computer Facility, Clinical Neurophysiology Laboratory, Department of Neurology, Harvard Medical School, and the Massachusetts General Hospital, Boston.


Footnotes

Accepted for publication March 19, 1978.

Reprint requests to EEG Laboratory, Massachusetts General Hospital, Boston, MA 02114 (Dr Chiappa).



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