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Comparison of Teratogenic Effects

Ruta B. Paulson, DDS; George W. Paulson, MD; Salim Jreissaty, MS

Arch Neurol. 1979;36(13):832-836.

Abstract
• The teratogenic activity of two anticonvulsant drugs, phenytoin sodium and carbamazepine, was studied in pregnant mice fed phenytoin and carbamazepine during days 8 to 13. Incidence of palatal defects and other abnormalities correlated with increasing dosages and blood levels of the drugs. Phenytoin produced a much higher incidence of teratogenic effects than carbamazepine.

Author Affiliations
From the College of Dentistry (Dr R. Paulson and Mr Jreissaty) and the Department of Neurology (Dr G. Paulson), Ohio State University, and Riverside Methodist Hospital (Dr W. Paulson), Columbus.

Footnotes
Accepted for publication Jan 7, 1979.

Read before the 11th World Congress in Neurology, Amsterdam, Sept 15, 1977.

Reprint requests to College of Dentistry, Ohio State University, 305 W 12th Ave, Columbus, OH 43210 (Dr R. B. Paulson).

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ABSTRACT