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Forbes H. Norris, Jr, MD; Kwei Sang U, MD; Barry Sachais, PhD; Michael Carey, MD

Arch Neurol. 1979;36(11):715-716.

Abstract
• A trial of the antispastic drug baclofen was made in amyotrophic lateral sclerosis. Some patients noted reduction of tonus and spasticity; but others had no benefit, nor was the course of the disease altered by long-term administration of baclofen. No major side effects occurred.

Author Affiliations
From the Institutes of Medical Sciences, San Francisco (Drs Norris and U), and the Medical Department, Pharmaceutical Division, CIBA-Geigy Corp, Summit, NJ (Drs Sachais and Carey).

Footnotes
Accepted for publication Nov 2, 1978.

Reprint requests to ALS Research Center, Institutes of Medical Sciences, 2200 Webster Street, San Francisco, CA 94115 (Dr Norris).

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