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Effect of Intracerebral Vasculitis on Regional Cerebral Blood Flow
Jesse Weinberger, MD;
John Gordon, PhD;
Andrew K. Hodson, MB, CHB, MRCP;
Herbert I. Golberg, MD;
Martin Reivich, MD
Arch Neurol. 1979;36(11):681-685.
Abstract
• Regional cerebral blood flow was measured by the xenon 133-inhalation method in a 40-year-old man during an acute exacerbation of intracranial vasculitis. Neurologic function was quantitated by the Halstead-Reitan Neuropsychological test battery. The patient was also studied during remission that was induced by steroid therapy. Vasculitis produced a diffuse encephalopathy with generalized reduction in cerebral blood flow. During remission, only focal symptoms secondary to a small cerebral infarction remained and regional cerebral blood flow returned to the normal range. There seems to be a close correlation between the severity of symptoms in cerebral vasculitis and reduction of flow through diseased vessels.
Author Affiliations
From the Cerebrovascular Research Center (Drs Weinberger, Gordon, Goldberg, and Reivich) and the Department of Neurology (Drs Weinberger, Hodson, and Reivich), Hospital of the University of Pennsylvania, Philadelphia. Dr Weinberger is currently at the Mount Sinai School of Medicine, New York.
Footnotes
Accepted for publication Jan 14, 1978.
Reprint requests to Cerebrovascular Research Center, Fourth Floor Piersol Building, Hospital of the University of Pennsylvania, Philadelphia, PA 19104 (Dr Reivich).
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