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Arthur C. Klassen, MD; Lois M. Heaney; Myoung C. Lee, MD; Fernando Torres, MD

Arch Neurol. 1979;36(10):627-629.

Abstract
• To determine the effect of inhaled carbon dioxide on acute ischemic cerebral injury, we have compared occipital visual evoked responses (VER) at baseline and during hypercapnia in 20 patients with acute unilateral cerebral infarction (ten with and ten without homonymous hemianopsia) and in ten normal controls. Visual evoked responses were judged on the basis of interhemispheral symmetry. In eight of ten controls and six of 20 patients, baseline VERs were symmetrical and remained unchanged during hypercapnia. In 14 patients with asymmetrical baseline VERs, hypercapnia caused improvement of symmetry in five, worsening in three, and no change in six. Hypercapnic vasodilation may be either beneficial or deleterious to cerebral function in patients with acute cerebral infarction.

Author Affiliations
From the Department of Neurology, University of Minnesota, Minneapolis.

Footnotes
Accepted for publication Oct 29, 1978.

Read in part before the 12th Canadian Congress of Neurological Sciences, Quebec, June 18, 1977.

Reprint requests to Department of Neurology, Box 295 Mayo, University of Minnesota, Minneapolis, MN 55455 (Dr Klassen).

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