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A Clinicopathologic Study

Danny G. Harvey, MD; Richard M. Torack, MD; Herbert E. Rosenbaum, MD

Arch Neurol. 1979;36(10):615-617.

Abstract
• Ophthalmoplegia is rarely observed in patients with amyotrophic lateral sclerosis (ALS). We describe a patient with ALS in whom ophthalmoplegia, initially appearing midway in her course, progressed to total paralysis of extraocular movements by the time of death. In addition to the usual postmortem findings of ALS in the brain stem and spinal cord, there was extensive neuronal loss and gliosis involving the caudal portions of the dorsal and intermediate components of the oculomotor nuclei, the caudal part of the trochlear nuclei, and the abducens nuclei. This represents the first detailed report of the findings in the nuclei of cranial nerves III, IV, and VI in a patient with ALS and ophthalmoplegia.

Author Affiliations
From the Division of Neuropathology, Department of Pathology (Drs Harvey and Torack) and the Department of Neurology and Neurological Surgery (Dr Rosenbaum), Washington University School of Medicine, St Louis. Dr Harvey is now at Baylor College of Medicine, Houston.

Footnotes
Accepted for publication Nov 24, 1978.

Reprint requests to Department of Neurology and Neurological Surgery, Washington University School of Medicine, Barnes Hospital Plaza, 660 S Euclid Ave, St Louis, MO 63110 (Dr Rosenbaum).

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