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A Controlled Clinical Trial in Focal Motor and Generalized Epilepsy

Michael Kosteljanetz, MD; Johannes Christiansen, PhD; Agnete Mouritzen Dam, MD; Birger Stensgaard Hansen, MD; Birgit Blatt Lyon, MD; Holger Pedersen, MD; Mogens Dam, MD

Arch Neurol. 1979;36(1):22-24.

Abstract
• The antiepileptic effects of carbamazepine and phenytoin were compared in a double-blind crossover trial studying patients with primary and secondary generalized seizures and partial seizures with motor symptoms. Each treatment period lasted ten weeks. The patients were seen every two weeks, and doses were adjusted according to plasma levels. It was attempted to keep levels in the optimal plasma range, ie, 10 to 20 and 4 to 10 mg/liter for phenytoin and carbamazepine, respectively. Twenty-three patients entered and 19 completed the study. No statistically significant differences were found between carbamazepine and phenytoin with regard to seizure control and acute side effects.

Author Affiliations
From the University Clinic of Neurology, Hvidovre (Denmark) Hospital.

Footnotes
Accepted for publication March 6, 1978.

Deceased.

Reprint requests to University Clinic of Neurology, Hvidovre Hospital, DK-2650 Hvidovre, Denmark (Dr M. Dam).

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