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Moris J. Danon, MD; Wayne E. Marshall, PhD; Gunseli Sarpel, MD; Akira Omachi, PhD

Arch Neurol. 1978;35(9):592-595.

Abstract
• Erythrocytes from patients with Duchenne's and myotonic muscular dystrophies contained more adenosine triphosphate (ATP) and produced more lactate than did normal erythrocytes in incubation studies conducted in vitro at an initial pH of 7.4. Since the same results were obtained in two different genetic dystrophies, these metabolic variations appear to be secondary to the primary changes occurring in these diseases. Following ouabain treatment, ATP content increased and lactate production decreased in erythrocytes from both dystrophies. This result differs from one reported earlier in experiments conducted at alkaline pH.

Author Affiliations
From the Departments of Neurology (Drs Danon and Sarpel) and Physiology and Biophysics (Drs Marshall and Omachi), University of Illinois Medical Center, Chicago.

Footnotes
Accepted for publication Nov 3, 1977.

Read in part before the 29th annual meeting of the American Academy of Neurology, Atlanta, April 25, 1977.

Reprint requests to Department of Neurology, University of Illinois Medical Center, 912 S Wood St, Chicago, IL 60612 (Dr Danon).

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ABSTRACT