Decreased spinal cord cGMP in murine (wobbler) spontaneous lower motor neuron degeneration
B. R. Brooks, W. D. Lust, J. M. Andrews and W. K. Engel
Of the secondary messengers, cyclic quanosine monophosphate, but not cyclic
adenosine monophosphate, was reduced by 80% in the cervical spinal cord and
by 56% in the cerebellum of clinically affected homozygote "wobbler" mice
compared to sex- and age-matched litter-mate clinically unaffected control
mice. A neurotransmitter, gamma aminobutyric acid, and high-energy
intermediates, adenosine triphosphate and phosphocreatine, were not
significantly different in affected or unaffected mice.