Comparison of the neuropsychological deficits associated with early and advanced Huntington's disease
N. Butters, D. Sax, K. Montgomery and S. Tarlow
Patients with "recently" diagnosed Huntington's Disease (RHD) were compared
on a neuropsychological test battery to patients who have had the disease
three to 15 years (AHD) and to intact controls. While the patients with HD
showed general nonfocal deficits on the Wechsler Adult Intelligence Scale,
the Wechsler Memory Scale, and tests of short-term memory and verbal
fluency, the patients with RHD had focal deficits that stressed their
memory deficits. The patients with RHD had IQs within the normal range, but
their memory quotients, their performance on short-term memory tests, and
their ability to search and retrieve from long-term memory were severely
imparied. These results suggest that the cognitive deficits of patients
with HD do not develop uniformally; memory disorders are early focal signs
that precede the patients' more widespread intellectual deterioration.
Dorsolateral prefrontal cortex dysfunction in presymptomatic Huntington's disease: evidence from event-related fMRI
Wolf et al.
Brain 2007;130:2845-2857.
ABSTRACT
| FULL TEXT
Profile of cognitive progression in early Huntington's disease
Ho et al.
Neurology 2003;61:1702-1706.
ABSTRACT
| FULL TEXT
Basal-ganglia 'Projections' to the Prefrontal Cortex of the Primate
Middleton and Strick
Cereb Cortex 2002;12:926-935.
ABSTRACT
| FULL TEXT
Retest effects and cognitive decline in longitudinal follow-up of patients with early HD
Bachoud-Levi et al.
Neurology 2001;56:1052-1058.
ABSTRACT
| FULL TEXT
Decreased Memory Performance in Healthy Humans Induced by Stress-Level Cortisol Treatment
Newcomer et al.
Arch Gen Psychiatry 1999;56:527-533.
ABSTRACT
| FULL TEXT
Cognitive Profiles of Autopsy-Confirmed Lewy Body Variant vs Pure Alzheimer Disease
Connor et al.
Arch Neurol 1998;55:994-1000.
ABSTRACT
| FULL TEXT
Severity of Cognitive Impairment in Juvenile and Late-Onset Huntington Disease
Gomez-Tortosa et al.
Arch Neurol 1998;55:835-843.
ABSTRACT
| FULL TEXT
Are cognitive changes the first symptoms of Huntington's disease? A study of gene carriers
Hahn-Barma et al.
J. Neurol. Neurosurg. Psychiatry 1998;64:172-177.
ABSTRACT
| FULL TEXT
Frontal Behavioral Syndromes in Cortical and Subcortical Dementia
Paulsen et al.
Assessment 1996;3:327-337.
ABSTRACT
Chronic 3-Nitropropionic Acid Treatment in Baboons Replicates the Cognitive and Motor Deficits of Huntington''s Disease
Palfi et al.
J. Neurosci. 1996;16:3019-3025.
ABSTRACT
| FULL TEXT
Anatomical evidence for cerebellar and basal ganglia involvement in higher cognitive function
Middleton and Strick
Science 1994;266:458-461.
ABSTRACT
Lexical Processing in Parkinson's Disease and Multiple Sclerosis
Beatty and Monson
J Geriatr Psychiatry Neurol 1989;2:145-152.
ABSTRACT
Cognitive Disturbances in Parkinson's Disease
Beatty et al.
J Geriatr Psychiatry Neurol 1989;2:22-33.
ABSTRACT