This Article  • References  • Full text PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Nelson Butters, PhD; Daniel Sax, MD; Kathleen Montgomery; Susan Tarlow

Arch Neurol. 1978;35(9):585-589.

Abstract
• Patients with "recently" diagnosed Huntington's Disease (RHD) were compared on a neuropsychological test battery to patients who have had the disease three to 15 years (AHD) and to intact controls. While the patients with HD showed general nonfocal deficits on the Wechsler Adult Intelligence Scale, the Wechsler Memory Scale, and tests of short-term memory and verbal fluency, the patients with RHD had focal deficits that stressed their memory deficits. The patients with RHD had IQs within the normal range, but their memory quotients, their performance on short-term memory tests, and their ability to search and retrieve from long-term memory were severely impaired. These results suggest that the cognitive deficits of patients with HD do not develop uniformally; memory disorders are early focal signs that precede the patients' more widespread intellectual deterioration.

Author Affiliations
From the Psychology Service, Boston Veterans Administration Hospital (Dr Butters, and Ms Montgomery and Tarlow); the Neurology Services, Veterans Administration Outpatient Clinic (Dr Sax); and the Boston University School of Medicine (Drs Butters and Sax).

Footnotes
Accepted for publication Nov 7, 1977.

Reprint requests to Psychology Service, Boston Veterans Administration Hospital, 150 S Huntington Ave, Boston, MA 02130 (Dr Butters).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Toxic Effects of Depression on Brain Function: Impairment of Delayed Recall and the Cumulative Length of Depressive Disorder in a Large Sample of Depressed Outpatients
Gorwood et al.
Am. J. Psychiatry 2008;165:731-739.
ABSTRACT | FULL TEXT  

Dorsolateral prefrontal cortex dysfunction in presymptomatic Huntington's disease: evidence from event-related fMRI
Wolf et al.
Brain 2007;130:2845-2857.
ABSTRACT | FULL TEXT  

Profile of cognitive progression in early Huntington's disease
Ho et al.
Neurology 2003;61:1702-1706.
ABSTRACT | FULL TEXT  

Basal-ganglia 'Projections' to the Prefrontal Cortex of the Primate
Middleton and Strick
Cereb Cortex 2002;12:926-935.
ABSTRACT | FULL TEXT  

Retest effects and cognitive decline in longitudinal follow-up of patients with early HD
Bachoud-Levi et al.
Neurology 2001;56:1052-1058.
ABSTRACT | FULL TEXT  

Decreased Memory Performance in Healthy Humans Induced by Stress-Level Cortisol Treatment
Newcomer et al.
Arch Gen Psychiatry 1999;56:527-533.
ABSTRACT | FULL TEXT  

Cognitive Profiles of Autopsy-Confirmed Lewy Body Variant vs Pure Alzheimer Disease
Connor et al.
Arch Neurol 1998;55:994-1000.
ABSTRACT | FULL TEXT  

Severity of Cognitive Impairment in Juvenile and Late-Onset Huntington Disease
Gomez-Tortosa et al.
Arch Neurol 1998;55:835-843.
ABSTRACT | FULL TEXT  

Are cognitive changes the first symptoms of Huntington's disease? A study of gene carriers
Hahn-Barma et al.
J. Neurol. Neurosurg. Psychiatry 1998;64:172-177.
ABSTRACT | FULL TEXT  

Cognitive Manifestations of Huntington Disease in Relation to Genetic Structure and Clinical Onset
Jason et al.
Arch Neurol 1997;54:1081-1088.
ABSTRACT  

An Electrophysiological Analysis of Altered Cognitive Functions in Huntington Disease
Munte et al.
Arch Neurol 1997;54:1089-1098.
ABSTRACT  

Frontal Behavioral Syndromes in Cortical and Subcortical Dementia
Paulsen et al.
Assessment 1996;3:327-337.
ABSTRACT  

Psychiatric Symptoms Do Not Correlate With Cognitive Decline, Motor Symptoms, or CAG Repeat Length in Huntington's Disease
Zappacosta et al.
Arch Neurol 1996;53:493-497.
ABSTRACT  

Chronic 3-Nitropropionic Acid Treatment in Baboons Replicates the Cognitive and Motor Deficits of Huntington''s Disease
Palfi et al.
J. Neurosci. 1996;16:3019-3025.
ABSTRACT | FULL TEXT  

Longitudinal Neuropsychological and Genetic Linkage Analysis of Persons at Risk for Huntington's Disease
Giordani et al.
Arch Neurol 1995;52:59-64.
ABSTRACT  

Anatomical evidence for cerebellar and basal ganglia involvement in higher cognitive function
Middleton and Strick
Science 1994;266:458-461.
ABSTRACT  

Unimpaired Verbal Memory and Oculomotor Control in Asymptomatic Adults With the Genetic Marker for Huntington's Disease
Rothlind et al.
Arch Neurol 1993;50:799-802.
ABSTRACT  

Frontal-Subcortical Circuits and Human Behavior
Cummings
Arch Neurol 1993;50:873-880.
ABSTRACT  

Frontal Lobe Dysfunction in Unilateral Lenticulostriate Infarcts: Prominent Role of Cortical Lesions
Godefroy et al.
Arch Neurol 1992;49:1285-1289.
ABSTRACT  

Ideomotor Apraxia in Huntington's Disease
Shelton and Knopman
Arch Neurol 1991;48:35-41.
ABSTRACT  

Are There Neuropsychologic Manifestations of the Gene for Huntington's Disease in Asymptomatic, At-Risk Individuals?
Strauss and Brandt
Arch Neurol 1990;47:905-908.
ABSTRACT  

Regional Cerebral Blood Flow and Cognitive Function in Huntington's Disease and Schizophrenia: A Comparison of Patients Matched for Performance on a Prefrontal-Type Task
Goldberg et al.
Arch Neurol 1990;47:418-422.
ABSTRACT  

Differentiation of Alzheimer's Disease and Huntington's Disease With the Dementia Rating Scale
Salmon et al.
Arch Neurol 1989;46:1204-1208.
ABSTRACT  

Cognitive Disturbances in Patients With Relapsing Remitting Multiple Sclerosis
Beatty et al.
Arch Neurol 1989;46:1113-1119.
ABSTRACT  

Lexical Processing in Parkinson's Disease and Multiple Sclerosis
Beatty and Monson
J Geriatr Psychiatry Neurol 1989;2:145-152.
ABSTRACT  

Cognitive Disturbances in Parkinson's Disease
Beatty et al.
J Geriatr Psychiatry Neurol 1989;2:22-33.
ABSTRACT  

Presymptomatic Neuropsychological Impairment in Huntington's Disease
Jason et al.
Arch Neurol 1988;45:769-773.
ABSTRACT  

Anterograde and Retrograde Amnesia in Patients With Chronic Progressive Multiple Sclerosis
Beatty et al.
Arch Neurol 1988;45:611-619.
ABSTRACT  

A Controlled Neuropsychological Comparison of Huntington's Disease and Multiple Sclerosis
Caine et al.
Arch Neurol 1986;43:249-254.
ABSTRACT  

Isolated Impairment of Memory Following a Penetrating Lesion of the Fornix Cerebri
Grafman et al.
Arch Neurol 1985;42:1162-1168.
ABSTRACT  

Dissociations Between Skill Learning and Verbal Recognition in Amnesia and Dementia
Martone et al.
Arch Neurol 1984;41:965-970.
ABSTRACT  

Subcortical Dementia: Review of an Emerging Concept
Cummings and Benson
Arch Neurol 1984;41:874-879.
ABSTRACT  

Development of Neuropsychological Deficits in Huntington's Disease
Josiassen et al.
Arch Neurol 1983;40:791-796.
ABSTRACT  

Pseudodementia: Current Concepts and Future Directions
Caine
Arch Gen Psychiatry 1981;38:1359-1364.
ABSTRACT