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A Study in Experimental Animals

Harold A. Wilkinson, MD, PhD; David Arredondo; Samuel Weems; Debra Kaner

Arch Neurol. 1978;35(9):567-576.

Abstract
• Quantitating cerebral "elastance" or "ICP reserve" has added considerably to the value of continuous monitoring of intracranial pressure (ICP). Intracranial pressure reserve is a measure of the capacity of the brain's natural compensatory mechanisms for countering increases in ICP secondary to increases in intracranial volume.

Intracranial pressure reserve testing was studied in dogs with known volumes of extracerebral intracranial mass, both in normal and in edematous brains and at various ICPs. Ten thousand measurements were made with five different methods of measuring ICP reserve. Testing when multiple increments of subdural saline infusion were used over a fiveminute period to quantitate ICP reactivity to volumetric stress seemed most reliable and most adaptable to clinical application. Methods of measuring cerebral "elastance" using only a single subdural infusion proved to be variable and difficult to read.

Author Affiliations
From Harvard Neurosurgery, Beth Israel Hospital, Boston.

Footnotes
Accepted for publication Nov 30, 1977.

Reprint requests to Harvard Neurosurgery, Beth Israel Hospital, 330 Brookline Ave, Boston, MA 02215 (Dr Wilkinson).

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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Intracranial Pressure Reserve Testing: Initial Clinical Observations
Wilkinson
Arch Neurol 1978;35:661-667.
ABSTRACT