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Evidence for an Interaction of Hemopexin With Myoglobin-Derived Heme

Bruce T. Adornato, MD; Lawrence J. Kagen, MD; Fred A. Garver, PhD; W. King Engel, MD

Arch Neurol. 1978;35(8):547-548.

Abstract
• Hemopexin is a normal serum glycoprotein that functions as a carrier for intravascularly liberated free heme. Although its role is well established in the reutilization of hemoglobin-derived heme, there have been no previous clinical data to support its suspected interaction with heme released in the degradation of myoglobin. In a Patient with fulminant rhabdomyolysis, we found depletion of serum hemopexin in the presence of high serum levels of myoglobin with normal levels of haptoglobin and hemoglobin. This combination of laboratory findings is evidence for an interaction between myoglobin-derived heme and hemopexin and implies a role for hemopexin in the catabolism of myoglobin. These findings support the proposed induction mechanism for observed increases of serum hemopexin in Duchenne muscular dystrophy and in polymyositis.

Author Affiliations
From the Medical Neurology Branch, National Institute of Neurological and Communicative Disorders and Stroke, Bethesda, Md, (Drs Adornato and Engel), the Hospital for Special Surgery, Cornell University Medical College, New York, (Dr Kagen), and the Department of Cellular and Molecular Biology, Medical College of Georgia, Augusta, (Dr Garver). Dr Adornato is now at the Palo Alto Medical Clinic, Palo Alto, Calif.

Footnotes
Accepted for publication Dec 23, 1977.

Reprint requests to Medical Neurology Branch, National Institute of Neurological and Communicative Disorders and Stroke, Bethesda, MD 20014 (Dr Engel).

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