 |
|
Internuclear OphthalmoplegiaI. Saccades and Dissociated Nystagmus
Robert W. Baloh, MD;
Robert D. Yee, MD;
Vincente Honrubia, MD
Arch Neurol. 1978;35(8):484-489.
Abstract
| |
• Saccades (horizontal and vertical) and dissociated nystagmus were quantitatively assessed in four patients with internuclear ophthalmoplegia. Two patients had bilateral medial longitudinal fasciculus (MLF) lesions associated with multiple sclerosis and two had unilateral lesions associated with brain stem vascular disease.
Adducting saccades made on the side of an MLF lesion were slowed in each patient (P <.01). At the same time, abducting saccades in the contralateral eye had normal velocity, but consistently overshot the target. After the overshoot, the eye returned to the target with an exponentially decaying course. With large angular deviations (usually more than 15°), the abducting eye developed nystagmus characterized by slow components that moved toward the midposition with an initially high velocity followed by a segment of slower velocity. The adducting eye had either no nystagmus or a low-amplitude nystagmus characterized by a rounded junction between the fast and slow component. The saccade abnormalities and waveform of the dissociated nystagmus can be explained by a pulsestep mismatch at the agonist motoneurons.
Author Affiliations
From the Department of Neurology, Reed Neurological Research Center (Dr Baloh); Department of Ophthalmology, Jules Stein Eye Institute (Dr Yee); and Division of Head and Neck Surgery (Dr Honrubia); UCLA School of Medicine, Los Angeles.
Footnotes
Accepted for publication April 11, 1977.
Reprint requests to Department of Neurology, Reed Neurological Research Center, Center for the Health Sciences, UCLA, Los Angeles, CA 90024 (Dr Baloh).
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati
What's this?
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
Pearls & Oy-sters: The medial longitudinal fasciculus in ocular motor physiology
Frohman et al.
Neurology 2008;70:e57-e67.
ABSTRACT
| FULL TEXT
Dissociated Vertical Nystagmus and Internuclear Ophthalmoplegia From a Midbrain Infarction
Marshall et al.
Arch Neurol 1991;48:1304-1305.
ABSTRACT
The Clinical Spectrum of Internuclear Ophthalmoplegia in Multiple Sclerosis
Muri and Meienberg
Arch Neurol 1985;42:851-855.
ABSTRACT
Analysis of Characteristic Eye Movement Abnormalities in Internuclear Ophthalmoplegia
Crane et al.
Arch Ophthalmol 1983;101:206-210.
ABSTRACT
Upbeat Nystagmus and Internuclear Ophthalmoplegia With Brainstem Glioma
Troost et al.
Arch Neurol 1980;37:453-456.
ABSTRACT
|
