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Possible Role of Dopamine Autoreceptors

Eduardo S. Tolosa, MD

Arch Neurol. 1978;35(7):459-462.

Abstract
• A group of 16 patients afflicted with involuntary movement disorders received subcutaneous injections of the direct dopamine agonist, apomorphine hydrochloride. Paradoxically, these injections were generally followed by a reduction of dyskinesia; this was most noticeable in patients with tardive dyskinesia and was only mild in some patients with spasmodic torticollis. Preferential stimulation by apomorphine of inhibitory dopamine presynaptic receptors (so-called dopamine autoreceptors) is proposed as the most likely explanation for the observed antidyskinetic effect of this drug. The results of this study also suggest that direct dopamine agonists may be used clinically to attenuate CNS dopaminergic transmission, especially when use of antidopminergic drugs such as the neuroleptics is contraindicated, as in the case of tardive dyskinesia.

Author Affiliations
From the Department of Neurology, University of Minnesota School of Medicine, Minneapolis.

Footnotes
Accepted for publication Sept 26, 1977.

Reprint requests to Department of Neurology, Box 468-Mayo, University of Minnesota School of Medicine, Minneapolis, MN 55455 (Dr Tolosa).

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