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Absence of Increased Response in Amyotrophic Lateral Sclerosis and Multiple Sclerosis

Richard J. Kascsak, PhD; Robert E. Shope, MD; Hyman Donnenfeld, MD; Harry Bartfeld, MD

Arch Neurol. 1978;35(7):440-442.

Abstract
• Complement fixation and hemagglutination inhibition tests were conducted on the serums of patients with amyotrophic lateral sclerosis and multiple sclerosis using a variety of arboviral antigens. Seventy-eight complement fixation and 15 hemagglutination-inhibition viral antigens were used representing togaviruses, orbiviruses, rhadoviruses, bunyaviruses, arenaviruses, and several ungrouped agents. The serological results did not indicate any relationship between these viruses and either amyotrophic lateral sclerosis or multiple sclerosis.

Author Affiliations
From the New York State Institute for Basic Research in Mental Retardation (Dr Kascsak), New York, the Yale Arbovirus Research Unit (Dr Shope), New Haven, Conn, and St Vincent's Hospital (Drs Donnenfeld and Bartfeld), New York.

Footnotes
Accepted for publication Nov 29, 1977.

Reprint requests to New York State Institute for Basic Research in Mental Retardation, 1050 Forest Hill Rd, Staten Island, NY 10314 (Dr Kascsak).

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