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Steven Lebow, MD; David C. Anderson, MD; Angeline Mastri, MD; David Larson, MD

Arch Neurol. 1978;35(7):435-439.

Abstract
• In a case of clinically fulminant multiple sclerosis (MS), contrast-enhancing lesions were visible by computerized axial tomography (CT). The patient died less than three weeks after the study, making neuropathologic correlation possible. It appears that areas of contrast enhancement correlate in acute MS with early demyelinative lesions, and enhancement is related to breakdown of the blood-brain barrier. That such a disturbance is important in the pathogenesis of demyelination in MS has been suggested by other data as well. The characteristic CT findings of MS must therefore include enhancing lesions that reflect disease activity and that may be the only CT abnormality.

Author Affiliations
From the Departments of Neurology, Hennepin County Medical Center and the University of Minnesota Medical School, Minneapolis.

Footnotes
Accepted for publication Oct 3, 1977.

Reprint requests to Department of Neurology, Hennepin County Medical Center, 701 Park Ave South, Minneapolis, MN 55415 (Dr Anderson).

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