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Deposition of M Component on Myelin Sheaths

Jean Julien, MD; Claude Vital, MD; Jean-Michel Vallat, MD; Alain Lagueny, MD; Colette Deminiere, MD; Danielle Darriet, MD

Arch Neurol. 1978;35(7):423-425.

Abstract
• A chronic sensory neuropathy was the initial symptom in a case of Waldenström's macroglobulinemia in a 53-year-old woman.

Ultrastructural analysis of a biopsied peripheral nerve revealed a modification of the lamellar structure of the myelin sheath. Immunofluorescent microscopy showed IgM-positive deposits on the myelin sheath. The monoclonal globulin (M component) present in the myelin appears to be a causative factor in the neuropathy.

Author Affiliations
From the Department of Neurology, Hôpital du Haut-Lévêque (Drs Julien, Vallat, Lagueny, and Darriet), and the Jean Abadie Neuropathology Center (Drs Vital and Deminiere), Bordeaux, France.

Footnotes
Accepted for publication Sept 9, 1977.

Reprint requests to Service de Neurologie, Hôpital du Haut-Lévêque, 33604 Bordeaux Pessac, France (Dr Julien).

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