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Transient Emboligenic AortoarteritisNoteworthy New Entity in Young Stroke Patients
Himansu R. Wickremasinghe, MBBS, DPath, PhD;
Jayantha B. Peiris, MD, MRCP;
Pujitha N. Thenabadu, MD, MRCP;
Abdual H. Sheriffdeen, MB, FRCS
Arch Neurol. 1978;35(7):416-422.
Abstract
• The clinical and postmortem anatomical data in a group of ten patients with occlusive cerebrovascular disease in the 15- to 40-year age group were studied.
The occlusion of the peripheral supply artery in the brain in all cases was found to be due to thromboemboli generated from focal thrombotic lesions situated proximally in the aorta and elastic arterial trunks arising from it. These central thrombotic lesions were caused by a transient form of focal aortoarteritis that primarily affects medial elastic tissue underlying the thrombi. This is a new disease entity, distinct from Takayasu's and other forms of segmental aortitis.
The pathogenesis of occlusive cerebrovascular disease in the young remains obscure in a majority of cases. In this context, the definition of this new entity is an important contribution to the understanding of nonatherogenic occlusive cerebrovascular disease.
Author Affiliations
From the Departments of Neuropathology, Neurology, Cardiac Investigation, and Surgery General Hospital, Colombo, Sri Lanka.
Footnotes
Accepted for publication Aug 16, 1977.
Reprint requests to 22/2 Kirimandala Mawatha, Nawala, Rajagiriya, Sir Lanka (Dr Wickremansinghe).
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