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Onset and End-of-Dose Levodopa-Induced DyskinesiasPossible Treatment by Increasing the Daily Doses of Levodopa
Francois Lhermitte, MD;
Yves Agid, MD;
Jean-Louis Signoret, MD
Arch Neurol. 1978;35(5):261-263.
Abstract
• Ballistic and dystonic involuntary movements occurring at the beginning and end of the period of levodopa efficacy are described in nine patients exhibiting dyskinesias during long-term levodopa therapy. In contrast to classical abnormal interdose movements, these biphasic dyskinesias were reduced by increasing and fractionating the daily doses of levodopa.
Author Affiliations
From the Department of Neurology and Neuropsychology, Hôpital de la Sâlpetrière, Paris.
Footnotes
Accepted for publication Sept 6, 1977.
Reprint requests to Department of Neurology and Neuropsychology, Hôpital de la Sâlpetrière, 47 bd de l'Hôpital, 75634 Paris Cedex 13, France (Dr Lhermitte).
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