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Two Hundred Patients With Optic Neuritis and/or Multiple Sclerosis

Fereydoun Shahrokhi, MD; Keith H. Chiappa, MD; Robert R. Young, MD

Arch Neurol. 1978;35(2):65-71.

Abstract
• Fifty-one patients with clinically pure optic neuritis (ON) and 149 with possible, probable, or definite multiple sclerosis (MS) were tested with pattern shift visual evoked responses (PSVER) and compared with a group of 43 normal subjects. Attention was paid to response latency, intereye latency difference, as well as differences in amplitude or duration of the major positive peak (P100). Abnormal PSVER cannot be recorded from everyone with confirmed ON. Abnormal responses were recorded from 91% of all patients (including those with MS) who had a history of ON, 57% of all MS patients, and 36% of patients without a history of ON or an abnormal eye examination. Measurements of amplitude and duration proved to be of little value in this setting. Though abnormalities of PSVER are not "specific" for ON or MS, because they also result from other disease processes, they afford more reliable, quantitative documentation of abnormal conduction in visual pathways than any other clinical test.

Author Affiliations
From the Laboratory of Clinical Neurophysiology, Department of Neurology, Massachusetts General Hospital and Haward Medical School, Boston. Dr Shahrokhi is now with the Department of Neurology, Louisiana State University Medical Center, Shreveport.

Footnotes
Accepted for publication Sept 6, 1977.

Read in part before the 30th annual meeting of the American Electroencephalography Society, Dearborn, Mich, Sept 29, 1976.

Reprint requests to Massachusetts General Hospital, Fruit Street, Boston, MA 02114 (Dr Young).

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