 |
|
Effect of an Opiate Antagonist on Movement Disorders
John G. Nutt, MD;
Arnold J. Rosin, MD;
Toomas Eisler, MB;
Donald B. Calne, DM;
Thomas N. Chase, MD
Arch Neurol. 1978;35(12):810-811.
Abstract
• Animal experiments suggest that opiate peptides might play a role in extrapyramidal function. This hypothesis was tested by administering the opiate antagonist, naltrexone, in doses sufficient to antagonize exogenous opiates, to patients with parkinsonism and Huntington's disease. No improvement in the clinical features of either disorder was noted.
Author Affiliations
From the Experimental Therapeutics Branch, Intramural Research Program, National Institute of Neurological and Communicative Disorders and Stroke, Bethesda, Md.
Footnotes
Accepted for publication Feb 16, 1978.
Reprint requests to National Institute of Neurological and Communicative Disorders and Stroke, Bldg 10, Room 2D11, National Institute of Health, Bethesda, MD 20014 (Dr Nutt).
 CiteULike  Connotea  Delicious  Digg  Facebook  Reddit  Technorati  Twitter
What's this?
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
The scientific and clinical basis for the treatment of Parkinson disease (2009)
Olanow et al.
Neurology 2009;72:S1-S136.
ABSTRACT
| FULL TEXT
New Therapeutic Approaches to Parkinson's Disease Including Neural Transplants
Kuan and Barker
Neurorehabil Neural Repair 2005;19:155-181.
ABSTRACT
An algorithm (decision tree) for the management of Parkinson's disease (2001):: Treatment
Olanow et al.
Neurology 2001;56:S1-S88.
FULL TEXT
Peptide-dopamine interactions in the central nervous system: implications for neuropsychiatric disorders
Stoessl
J Psychopharmacol 1989;3:99-120.
Effect of Naloxone on the 'On-Off' Syndrome in Patients Receiving Long-term Levodopa Therapy
Trabucchi et al.
Arch Neurol 1982;39:120-121.
ABSTRACT
Human Schwann Cells in Tissue Culture Histochemical and Ultrastructural Studies
Askanas et al.
Arch Neurol 1980;37:329-337.
ABSTRACT
|
