 |
|
Treatment of Parkinsonism With N-n-Propyl Norapomorphine and Levodopa (With or Without Carbidopa)
Paul S. Papavasiliou, MD;
George C. Cotzias, MD;
Victoria L. F. Rosal, RN;
Samuel T. Miller
Arch Neurol. 1978;35(12):787-791.
Abstract
• The effects of the concomitant administration of N-n-propyl norapomorphine (NPA) and levodopa, with and without carbidopa, were studied in 12 patients with unsatisfactory symptom control. Double-blind evaluation of the effects of NPA with suboptimal doses of levodopa or levodopa plus carbidopa (Sinemet) showed a mean overall improvement of 44% (20% to 74%) in nine patients and improvement of the "on-off" effect in five. Dyskinesia diminished in some patients after diminution of basal medication. In three patients, plasma dopa and growth hormone patterns did not differ substantially with and without NPA. The magnitude and timing of the therapeutic and side effects did not correlate with the pattern of growth hormone secretion, which suggests that this hormone might not be instrumental in the induction of these effects. N-n-propyl norapomorphine is a useful adjunct in the long-term management of patients with unsatisfactory response to levodopa.
Author Affiliations
From the Department of Neurology, Cornell University Medical College, New York.
Footnotes
Accepted for publication May 10, 1978.
Dr Cotzias died in June 1977.
Read in part before the American Academy of Neurology, Atlanta, April 30, 1977.
Reprint requests to New York Hospital-Cornell Medical Center, 525 E 68th St, New York, NY 10021 (Dr Papavasiliou).
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati
What's this?
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
Administration of Human Somatotropin in Levodopa-Treated Patients With Parkinsonism
Papavasiliou et al.
Arch Neurol 1979;36:624-626.
ABSTRACT
|
