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Garry Moddel, MD, FRCP(C); Juan M. Bilbao, MD, FRCP(C); David Payne, MD; Peter Ashby, MD, FRCP(C)

Arch Neurol. 1978;35(10):658-660.

Abstract
• A 35-year-old man developed a distal sensorimotor polyneuropathy after taking disulfiram, 500 mg daily for five months. His symptoms improved after the drug therapy was discontinued. Clinical, electrophysiological, and pathological observations during the acute stage and during recovery suggest that disulfiram produces a distal axonopathy.

Author Affiliations
From the University of Toronto, Toronto Western, and St Michael's Hospitals.

Footnotes
Accepted for publication Jan 19, 1978.

Read before the 12th Canadian Congress of Neurological Sciences, Quebec, June 1977.

Reprint requests to Toronto Western Hospital, 399 Bathurst St, Toronto, Canada M5T 2S8 (Dr Ashby).

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