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Apomorphine Hydrochloride-Induced Improvement in Huntington's ChoreaStimulation of Dopamine Receptor
Giovanni U. Corsini, MD;
PierLuigi Onali, MD;
Carmelo Masala, MD;
Carlo Cianchetti, MD;
Alfonso Mangoni, MD;
GianLuigi Gessa, MD
Arch Neurol. 1978;35(1):27-30.
Abstract
• Four patients affected by Huntington's chorea (HC) with a well defined family history of the disease were injected intramuscularly with apomorphine hydrochloride in nonemetic doses, ranging from 1 to 4 mg. Soon after treatment, all patients showed a marked decrease in abnormal involuntary movements. Pretreatment with haloperidol (2 mg intramuscularly) or sulpiride (100 mg intramuscularly) 30 minutes prior to apomorphine treatment, prevented the therapeutic effect of this compound. It is suggested that apomorphine-induced improvement in Huntington's Chorea is mediated by the stimulation of a special kind of dopamine receptor, leading to inhibition of the activity of dopaminergic neurons.
Author Affiliations
From the Department of Mental and Nervous Diseases (Drs Corsini, Onali, Masala, Cianchetti, and Mangoni) and Pharmacology (Dr Gessa).
Footnotes
Accepted for publication July 12, 1977.
Reprint requests to the Institute of Pharmacology, University of Cagliari, Cagliari, Italy (Dr Gessa).
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