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A Computerized Cranial Tomographic Study

Hilda Alcalá, MD; Mokhtar Gado, MD; Richard M. Torack, MD

Arch Neurol. 1978;35(1):1-7.

Abstract
• We correlated the radiologic and pathologic examination of 13 human brains, analyzing the size, different histologic elements, and water content in 40 ischemic and hemorrhagic infarcts. Acute infarcts appear in the computerized cranial tomographic (CT) image as low density areas due to high content of fluid, however, a histological-chemical correlation is not concomitant. The addition of blood in hemorrhagic infarcts may result in a normal CT image. Subacute infarcts appear as low density areas, with lower attenuation values due to the presence of large amounts of lipids. Subacute lesions with prominent mineral deposits may be negative on CT scan. Chronic infarcts also appear as low density areas due to cavitation and residual fats. Attenuation values are slightly higher than those of subacute infarcts, possibly due to gliosis. Infarcts smaller than 2 cm in diameter are usually not visualized.

Author Affiliations
From the Departments of Pathology (Neuropathology) (Drs Alcalá and Torack), and the Mallinckrodt Institute of Radiology (Neuroradiology) (Dr Gado), Washington University School of Medicine, St Louis.

Footnotes
Accepted for publication March 21, 1977.

Read in part before the 51st annual meeting of the American Association of Neuropathologists, New York, NY, May 31-June 1, 1975.

Reprint requests to Texas Children's Hospital, Department of Pathology, PO Box 20269, Houston TX 77030 (Dr Alcalá).

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