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Pharmacological Prophylaxis in the Kindling Model of Epilepsy
Juhn A. Wada, MD
Arch Neurol. 1977;34(7):389-395.
Abstract
• Review of antiepileptic drug assessment to date by means of the kindling model of epilepsy suggests that it fills a gap that is evident in standard screening methods such as maximum electroshock or pentylenetetrazol screening tests. However, in order to obtain a comprehensive profile of antiepileptic drugs regarding prophylaxis of developing seizures and treatment of well-established seizures through the kindling preparation, it is desirable to have the following: (1) standardization of kindling techniques, (2) examination of drug effects on developing as opposed to developed seizures, (3) use of a variety of animal species involving different functional brain sites, and (4) monitoring of plasma levels of the drug administered. It is envisaged that judicious use of the kindling preparation might also enable us to gain some insight into the mechanisms by which drugs produce their prophylactic or therapeutic effect.
Author Affiliations
From the Division of Neurological Science, Health Sciences Center Hospital, University of British Columbia, Vancouver, Canada.
Footnotes
Accepted for publication Feb 15, 1977.
Read before the American Epilepsy Society, New York, Dec 3, 1975.
Reprint requests to Division of Neurological Science, Health Sciences Center Hospital, University of British Columbia, 2075 Westbrook Pl, Vancouver, British Columbia, Canada V6T 1W5 (Dr Wada).
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