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Fairuz Matuk, MD; Krishna Kalyanaraman, MD

Arch Neurol. 1977;34(6):374-375.

Abstract
• We report two patients in whom the syndrome of inappropriate secretion of antidiuretic hormone (SIADH) developed during the administration of psychotherapeutic drugs. In one, the syndrome occurred after administration of a phenothiazine drug and in the other, a butyrophenone. Both the patients were diagnostically studied for evidence of other disorders, either neurologic or systemic, which could cause this syndrome with negative results. They responded to fluid and free water restriction with remarkable recovery and no sequelae. It is stressed that psychotherapeutic drug administration must be considered as one of the iatrogenic causes of SIADH.

Author Affiliations
From the Department of Neurology, State University of New York at Buffalo School of Medicine and the E. J. Meyer Memorial Hospital, Buffalo.

Footnotes
Accepted for publication Feb 7, 1977.

Reprint requests to the Department of Neurosciences, Peoria School of Medicine, Peoria, IL 61606 (Dr Kalyanaraman).

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