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Reversal of Delirium and Choreiform Movements With Tacrine Treatment

George Mendelson, MB, BS, MANZCP

Arch Neurol. 1977;34(5):313.

Abstract
• We describe a case of central anticholinergic syndrome with choreiform movements after an overdose of pheniramine aminosalicylate. The symptoms and signs of the condition were reversed by the intravenous administration of the cholinesterase-inhibitor tetrahydroaminacrine. We also discuss the concept of adrenergic-cholinergic imbalance in relation to this case and recommend the use of centrally acting anticholinesterase agents in the treatment of specific cases of drug overdose.

Author Affiliations
From the Department of Psychiatry, Prince Henry's Hospital, Melbourne 3004, Australia.

Footnotes
Accepted for publication Jan 13, 1977.

Reprint requests to the Department of Psychiatry, Prince Henry's Hospital, Melbourne 3004, Australia (Dr Mendelson).

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