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Zwi H. Hart, MD; Chung-Ho Chang, MD; Eugene V. D. Perrin, MD; Joseph S. Neerunjun, PhD; Ram Ayyar, MD

Arch Neurol. 1977;34(3):180-185.

Abstract
• We describe a 16-year-old boy who has a progressive dementia and seizures. On investigation, he was found to have a mitochondrial myopathy and elevated lactate levels in the blood and cerebrospinal fluid. His sister died at 18 years of age of a similar condition.

Author Affiliations
From the Department of Neurology (Drs Hart and Ayyar) and Pathology (Drs Chang and Perrin), Children's Hospital of Michigan, Wayne State University, Detroit, and the Jerry Lewis Muscle Research Center (Dr Neerunjun), Hammersmith Hospital, London.

Footnotes
Accepted for publication Nov 18, 1976.

Reprint requests to the Department of Neurology, Children's Hospital of Michigan, 3901 Beaubien Blvd, Detroit, MI 48201 (Dr Hart).

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