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III. Studies of Microbial Proteinase Inhibitors in Murine Dystrophy

Akira Enomoto, MD; Walter G. Bradley, MA, BSc, DM, FRCP

Arch Neurol. 1977;34(12):771-773.

Abstract
• The microbial antiproteinases—antipain, leupeptin, and pepstatin—have been reported to inhibit the degeneration of chicken dystrophic muscle in tissue culture. Trials of antipain and pepstatin, and of leupeptin and pepstatin administered subcutaneously in murine muscular dystrophy, failed to produce evidence of benefit. It is suggested that these antiproteinases cannot pass through an intact sarcolemma into muscle fibers. Further studies with liposomes may allow these agents to enter muscle fibers.

Author Affiliations
From the Third Department of Internal Medicine, Faculty of Medicine, University of Tokyo (Dr Enomoto); and the Department of Neurology, University of Newcastle upon Tyne, and the Muscular Dystrophy Group Research Laboratories, Newcastle General Hospital, Newcastle upon Tyne, England (Dr Bradley). Dr Bradley is now with the Department of Neurology, Tufts New England Medical Center, Boston.

Footnotes
Accepted for publication July 5, 1977.

Reprint requests to Department of Neurology, Tufts-New England Medical Center, 171 Harrison Ave, Boston, MA 02111 (Dr Bradley).