 |
|
Subclinical Optic Neuropathy in Multiple Sclerosis
Roderick J. Galvin, MB, MRCP;
James R. Heron, FRCPE;
David Regan, DSc
Arch Neurol. 1977;34(11):666-670.
Abstract
• Optic neuropathy in multiple sclerosis is often not detectable by conventional clinical assessment. Temporal resolution of vision was measured at localized retinal sites by a simple perceptual test of double light-flash discrimination. Nine of 11 multiple sclerosis patients with normal fundi and no prior history of optic neuritis displayed abnormal temporal resolution. Double-flash discrimination was consistently more sensitive than any of the clinical variables measured and in some cases complementary to them. The more advanced the disease, the more spatially widespread was the double-flash impairment in the central visual field. There was a significantly increased level of double-flash impairment in advanced multiple sclerosis patients compared with patients with spinal forms of the disease and with unilateral retrobulbar neuritis.
Author Affiliations
From the Department of Neurology, North Staffordshire Hospital Center, and the Research Unit, Medical Institute, Stoke-on-Trent, England (Drs Galvin and Heron), and the Department of Communication, University of Keele, Staffordshire (Prof Regan). Prof Regan is now with the Department of Psychology, Dalhousie University, Halifax, Nova Scotia.
Footnotes
Accepted for publication June 27, 1977.
Reprint requests to Department of Neurology, North Staffordshire Royal Infirmary, Hartshill, Stoke-on-Trent ST4 7LN England.
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
A Hypothesis-Based Approach to Clinical Psychophysics and to the Design of Visual Tests : The Proctor Lecture
Regan
IOVS 2002;43:1311-1323.
FULL TEXT
Visuoperceptual impairment in MS patients: nature and possible neural origins
Vleugels et al.
Mult Scler 2001;7:389-401.
ABSTRACT
Multiple Sclerosis Luminance Threshold and Measurements of Temporal Characteristics of Vision
Patterson et al.
Arch Neurol 1981;38:687-689.
ABSTRACT
|
