 |
|
Metabolic Anatomy of Focal Motor Seizures
Robert C. Collins, MD;
Charles Kennedy, MD;
Louis Sokoloff, MD;
Fred Plum, MD
Arch Neurol. 1976;33(8):536-542.
Abstract
| |
• Contralateral focal seizures occurred in rats following the intracortical injection of penicillin into the anterior motor cortex. The anatomic dimensions of the metabolic response in the focus as well as the spread of increased activity through the brain were studied by autoradiography following intravenous injection of carbon 14-labeled 2-deoxyglucose. Injections of 25 to 200 units of penicillin resulted in mild to severe contralateral motor jerks coincident with repetitive single spike discharges on the electroencephalogram. Concurrent autoradiography revealed a 1.3- to 2.5-fold increase in metabolic activity in discrete areas in ipsilateral cortex, basal ganglia, thalamus, and contralateral cerebellum. Intracortical injections of over 300 units resulted in the development of recurrent contralateral tonic-clonic seizures, with 20% becoming bilateral. In brains of these animals there was activation of bilateral medial frontal cortex, bilateral extrapyramidal system, thalamus, cerebellum, and limbic structures.
Author Affiliations
From the Department of Neurology, New York Hospital-Cornell Medical Center (Drs Collins and Plum), the Department of Pediatrics, Georgetown University School of Medicine, Washington, DC (Dr Kennedy), and the Laboratory of Cerebral Metabolism, National Institute of Mental Health, Bethesda, Md (Dr Sokoloff). Dr Collins is now with the Department of Neurology, Washington University School of Medicine, St Louis.
Footnotes
Accepted for publication Feb 11, 1975.
Reprint requests to Department of Neurology, Washington University School of Medicine, 660 S Euclid, St Louis, MO 63110 (Dr Collins).
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
Does Asymmetric Basal Ganglia or Thalamic Activation Aid in Seizure Foci Lateralization on Ictal SPECT Studies?
Sojkova et al.
JNM 2003;44:1379-1386.
ABSTRACT
| FULL TEXT
Effect of Divalproex-Lamotrigine Combination Therapy in Frontal Lobe Seizures
McCabe et al.
Arch Neurol 2001;58:1264-1268.
ABSTRACT
| FULL TEXT
Ictal Hyperperfusion of Cerebellum and Basal Ganglia in Temporal Lobe Epilepsy: SPECT Subtraction with MRI Coregistration
Shin et al.
JNM 2001;42:853-858.
ABSTRACT
| FULL TEXT
Focal cortical seizures cause distant thalamic lesions
Collins and Olney
Science 1982;218:177-179.
ABSTRACT
Patterns of human local cerebral glucose metabolism during epileptic seizures
Engel et al.
Science 1982;218:64-66.
ABSTRACT
Regional Cerebral Blood Flow and EEG in Patients With Epilepsy
Sakai et al.
Arch Neurol 1978;35:648-657.
ABSTRACT
Focal Motor Seizures-Reply
Collins
Arch Neurol 1977;34:57-58.
ABSTRACT
|
