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In Vivo Studies in Man

Marcus E. Raichle, MD; Robert L. Grubb, Jr, MD; Mokhtar H. Gado, MD; John O. Eichling, PhD; Michel M. Ter-Pogossian, PhD

Arch Neurol. 1976;33(8):523-526.

Abstract
• To test the hypothesis that regional cerebral blood flow (rCBF) is normally regulated by regional metabolic activity, rCBF and the regional cerebral metabolic rate for oxygen (rCMRO₂) were compared in selected human subjects. In normal subjects and patients with chronic, stable diseases of brain, rCBF correlated well with rCMRO₂. In one individual with mild dementia, rCBF and rCMRO₂ were measured before and during exercise of the hand and forearm contralateral to the hemisphere studied. Appropriate parallel changes occurred in both rCBF and rCMRO₂ during hand exercise. In patients with acute diseases affecting the hemisphere studied, however, the correlation between rCBF and rCMRO₂ was unpredictable.

Author Affiliations
From the Division of Radiation Sciences (Drs Raichle, Grubb, Eichling, and Ter-Pogossian), Mallinckrodt Institute of Radiology, and the departments of neurology and neurological surgery (Drs Raichle and Grubb) and radiology (Dr Gado), Washington University School of Medicine, St Louis.

Footnotes
Accepted for publication Sept 8, 1975.

Reprint requests to Division of Radiation Sciences, Box 8131, Washington University School of Medicine, St Louis, MO 63110 (Dr Raichle).

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