This Article  • References  • Full text PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

In Vivo Studies in Man

Marcus E. Raichle, MD; Robert L. Grubb, Jr, MD; Mokhtar H. Gado, MD; John O. Eichling, PhD; Michel M. Ter-Pogossian, PhD

Arch Neurol. 1976;33(8):523-526.

Abstract
• To test the hypothesis that regional cerebral blood flow (rCBF) is normally regulated by regional metabolic activity, rCBF and the regional cerebral metabolic rate for oxygen (rCMRO₂) were compared in selected human subjects. In normal subjects and patients with chronic, stable diseases of brain, rCBF correlated well with rCMRO₂. In one individual with mild dementia, rCBF and rCMRO₂ were measured before and during exercise of the hand and forearm contralateral to the hemisphere studied. Appropriate parallel changes occurred in both rCBF and rCMRO₂ during hand exercise. In patients with acute diseases affecting the hemisphere studied, however, the correlation between rCBF and rCMRO₂ was unpredictable.

Author Affiliations
From the Division of Radiation Sciences (Drs Raichle, Grubb, Eichling, and Ter-Pogossian), Mallinckrodt Institute of Radiology, and the departments of neurology and neurological surgery (Drs Raichle and Grubb) and radiology (Dr Gado), Washington University School of Medicine, St Louis.

Footnotes
Accepted for publication Sept 8, 1975.

Reprint requests to Division of Radiation Sciences, Box 8131, Washington University School of Medicine, St Louis, MO 63110 (Dr Raichle).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Energy limitation as a selective pressure on the evolution of sensory systems
Niven and Laughlin
J. Exp. Biol. 2008;211:1792-1804.
ABSTRACT | FULL TEXT  

Reduced cerebral blood flow response and compensation among patients with untreated hypertension
Jennings et al.
Neurology 2005;64:1358-1365.
ABSTRACT | FULL TEXT  

Neuroimaging With Calibrated fMRI
Hyder
Stroke 2004;35:2635-2641.
ABSTRACT | FULL TEXT  

Neuroanatomical Hypothesis of Panic Disorder, Revised
Gorman et al.
Focus 2004;2:426-439.
ABSTRACT | FULL TEXT  

Autoregulation of Blood Pressure and Thought: Preliminary Results of an Application of Brain Imaging to Psychosomatic Medicine
Jennings
Psychosom. Med. 2003;65:384-395.
ABSTRACT | FULL TEXT  

Evidence of thalamic disinhibition in patients with hemichorea: semiquantitative analysis using SPECT
Kim et al.
J. Neurol. Neurosurg. Psychiatry 2002;72:329-333.
ABSTRACT | FULL TEXT  

Correlation of cerebral hemodynamic changes during mental activity and recovery after stroke
Bragoni et al.
Neurology 2000;55:35-40.
ABSTRACT | FULL TEXT  

Neuroanatomical Hypothesis of Panic Disorder, Revised
Gorman et al.
Am. J. Psychiatry 2000;157:493-505.
ABSTRACT | FULL TEXT  

A model for the regulation of cerebral oxygen delivery
Hyder et al.
J. Appl. Physiol. 1998;85:554-564.
ABSTRACT | FULL TEXT  

The Neuropsychiatry of Chronic Cocaine Abuse
Bolla et al.
J. Neuropsychiatry Clin. Neurosi. 1998;10:280-289.
ABSTRACT | FULL TEXT  

Bilateral Hemispheric Activation in the Early Recovery of Motor Function After Stroke
Silvestrini et al.
Stroke 1998;29:1305-1310.
ABSTRACT | FULL TEXT  

Light Scattering Changes Follow Evoked Potentials From Hippocampal Schaeffer Collateral Stimulation
Rector et al.
J. Neurophysiol. 1997;78:1707-1713.
ABSTRACT | FULL TEXT  

Improving functional imaging techniques: The dream of a single image for a single mental event
Grabowski and Damasio
Proc. Natl. Acad. Sci. USA 1996;93:14302-14303.
FULL TEXT  

Accuracy of 133-xenon regional cerebral blood flow and quantitative electroencephalography in systemic lupus erythematosus
Nobili et al.
Lupus 1996;5:93-102.
ABSTRACT  

Effect of Acetazolamide on Regional Cerebral Oxygen Saturation and Regional Cerebral Blood Flow
Kaminogo et al.
Stroke 1995;26:2358-2360.
ABSTRACT | FULL TEXT  

Humanistic Neuroscience, Mentality, and Spirituality
Dennis
Journal of Humanistic Psychology 1995;35:34-72.
ABSTRACT  

Functional Neuroimaging With SPECT in Children With Partial Epilepsy
Harvey and Berkovic
J Child Neurol 1994;9:S71-S81.
ABSTRACT  

A prospective, randomized comparison of cerebral venous oxygen saturation during normothermic and hypothermic cardiopulmonary bypass
Cook et al.
J. Thorac. Cardiovasc. Surg. 1994;107:1020-1029.
ABSTRACT | FULL TEXT  

Brain Glucose Metabolism in Postanoxic Syndrome: Positron Emission Tomographic Study
DeVolder et al.
Arch Neurol 1990;47:197-204.
ABSTRACT  

Physiological Dysfunction of Dorsolateral Prefrontal Cortex in Schizophrenia: III. A New Cohort and Evidence for a Monoaminergic Mechanism
Weinberger et al.
Arch Gen Psychiatry 1988;45:609-615.
ABSTRACT  

Abnormal Resting Regional Cerebral Blood Flow Patterns and Their Correlates in Schizophrenia
Mathew et al.
Arch Gen Psychiatry 1988;45:542-549.
ABSTRACT  

Regional Cerebral Blood Flow in Severe Developmental Dyslexia
Rumsey et al.
Arch Neurol 1987;44:1144-1150.
ABSTRACT  

Cerebral Perfusion Imaging in Alzheimer's Disease: Use of Single Photon Emission Computed Tomography and Iofetamine Hydrochloride I 123
Johnson et al.
Arch Neurol 1987;44:165-168.
ABSTRACT  

Quantification of Intracerebral Steal in Patients With Arteriovenous Malformation
Homan et al.
Arch Neurol 1986;43:779-785.
ABSTRACT  

Physiologic Dysfunction of Dorsolateral Prefrontal Cortex in Schizophrenia: I. Regional Cerebral Blood Flow Evidence
Weinberger et al.
Arch Gen Psychiatry 1986;43:114-124.
ABSTRACT  

Local cerebral blood flow increases during auditory and emotional processing in the conscious rat
LeDoux et al.
Science 1983;221:576-578.
ABSTRACT  

Coupling Between Regional Blood Flow and Oxygen Utilization in the Normal Human Brain: A Study With Positron Tomography and Oxygen 15
Lebrun-Grandie et al.
Arch Neurol 1983;40:230-236.
ABSTRACT  

Sex and handedness differences in cerebral blood flow during rest and cognitive activity
Gur et al.
Science 1982;217:659-661.
ABSTRACT  

Regional Cerebral Blood Flow Correlates of Auditory Processing
Knopman et al.
Arch Neurol 1982;39:487-493.
ABSTRACT  

Regional Cerebral Blood Flow During Alcohol Withdrawal
Berglund and Risberg
Arch Gen Psychiatry 1981;38:351-355.
ABSTRACT  

Activation of the supplementary motor area during voluntary movement in man suggests it works as a supramotor area
Orgogozo and Larsen
Science 1979;206:847-850.
ABSTRACT  

Regional Cerebral Blood Flow in Aphasia
Soh et al.
Arch Neurol 1978;35:625-632.
ABSTRACT  

Regional Cerebral Blood Flow and EEG in Patients With Epilepsy
Sakai et al.
Arch Neurol 1978;35:648-657.
ABSTRACT  

Normal and Abnormal Patterns of Cerebrovascular Reserve Tested by 133Xe Inhalation
Meyer et al.
Arch Neurol 1978;35:350-359.
ABSTRACT