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Ronald Kartzinel, MD, PhD; Robert D. Hunt, MD; Donald B. Calne, MD

Arch Neurol. 1976;33(7):517-518.

Abstract
• Following a recent report that apomorphine hydrochloride alleviates the involuntary movements of Huntington chorea, we have investigated another dopamine receptor agonist, bromocriptine, in this disease. A double-blind crossover study in six patients showed that rather than improving chorea, bromocriptine induced an exacerbation. This finding supports the view that choreatic movements correlate with overactivity in dopaminergic systems.

Author Affiliations
From the Laboratory of Neuropharmacology, National Institute of Neurological and Communicative Disorders and Stroke, and the Laboratory of Clinical Sciences, National Institute of Mental Health, Bethesda, Md.

Footnotes
Accepted for publication Feb 11, 1976.

Reprint requests to Bldg 10, Room 6D20, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20014 (Dr Calne).

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